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Actinium Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company, focuses on developing and commercializing therapies for bone marrow transplant (BMT) or a type of cellular therapy, and for other adoptive cell therapies. Its lead product candidate, I-131 apamistamab (Iomab-B) that is in a pivotal Phase III clinical trial for elderly relapsed or refractory acute myeloid leukemia trial for BMT conditioning; and a Phase I study with a CD19- targeted CAR T-cell therapy with memorial sloan kettering cancer center. The company also offers clinical and preclinical development programs that utilize multiple isotopes, including Actinium-225, Iodine-131, and Lutetium-177 directed at multiple validated cancer targets, including CD45, CD33, CD38, CD47, HER2, and HER3 for targeted conditioning prior to cell and gene therapies, such as bone marrow transplant and cancer therapeutics as single agents or in combination with other therapeutic modalities. It has collaboration with Astellas Pharma, Inc. to develop theranostics for solid tumor indications; EpicentRx, Inc that focuses on a novel CD47 immunotherapy targeted radiotherapy; and AVEO Oncology that focuses on developing a HER3 targeting ARC for solid tumors. The company was incorporated in 2000 and is based in New York, New York.

Actinium Pharmaceuticals, Inc.

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- ATNM-400 EXHIBITS SUPERIOR EFFICACY WITH 3-5X GREATER TUMOR GROWTH INHIBITION COMPARED TO FRONT LINE THERAPY OSIMERTINIB (EGFR TKI TAGRISSO), SECOND LINE THERAPY DATO-DXD (TROP-2 ADC DATROWAY) AND THIRD LINE THERAPY AMIVANTAMAB (EGFR-CMET BISPECIFIC RYBREVANT) - COMBINATION OF ATNM-400 AND OSIMERTINIB RESULTED IN COMPLETE TUMOR REGRESSION IN 100% OF TUMOR BEARING ANIMALS; SYNERGISTIC MECHANISM SUPPORTED BY INCREASED ATNM-400 TARGET ANTIGEN EXPRESSION AFTER EGFR INHIBITION WITH OSIMERTINIB - IMPROVED PROGRESSION FREE SURVIVAL HAS BEEN DEMONSTRATED CLINICALLY WITH THE COMBINATION OF OSIMERTINIB AND EXTERNAL BEAM RADIOTHERAPY PROVIDING STRONG RATIONALE FOR A COMBINATION WITH TARGETED ALPHA-THERAPY - DATA VALIDATES THE MULTI-TUMOR POTENTIAL OF ATNM-400 IN MULTIPLE DISEASE AND TREATMENT SETTINGS THAT SUPPORT SEVERAL BLOCKBUSTER DRUGS NEW YORK , OCT. 27, 2025 /PRNEWSWIRE/ -- ACTINIUM PHARMACEUTICALS, INC.(NYSE AMERICAN: ATNM) (ACTINIUM OR THE COMPANY), A PIONEER IN THE DEVELOPMENT OF DIFFERENTIATED TARGETED RADIOTHERAPIES, TODAY ANNOUNCED THE PRESENTATION OF THE FIRST EVER PRECLINICAL DATA OF ATNM-400 IN NON-SMALL CELL LUNG CANCER (NSCLC). ATNM-400 A NOVEL, MULTI-INDICATION FIRST-IN-CLASS ANTIBODY RADIOCONJUGATE ARMED WITH THE POTENT ALPHA-EMITTER ACTINIUM-225 (AC-225) IS ACTINIUM'S LEAD SOLID TUMOR PROGRAM, WHICH IS ALSO BEING STUDIED IN PROSTATE CANCER.

ACTINIUM ANNOUNCES SUPERIOR ANTI-TUMOR ACTIVITY OF ATNM-400 IN LUNG CANCER COMPARED TO THE LEADING FIRST, SECOND AND THIRD-LINE APPROVED EGFR MUTANT THERAPIES AND MECHANISTIC SYNERGY WITH OSIMERTINIB AT THE AACR-NCI-EORTC INTERNATIONAL CONFERENCE ON MOLECULAR TARGETS AND CANCER THERAPEUTICS

- ATNM-400 TARGETS A NOVEL,NON-PSMA ANTIGEN IMPLICATED IN DISEASE BIOLOGY WITHCONTINUED EXPRESSION FOLLOWING ANDROGEN RECEPTOR PATHWAY INHIBITOR (ARPI) THERAPY AND 177LU-PSMA-617 THERAPY, ENABLING POTENT ACTIVITY INDEPENDENT OF PSMA EXPRESSION - ATNM-400 DEMONSTRATED SUPERIOR EFFICACY OVERPSMA-TARGETED RADIOLIGAND THERAPY(177LU-PSMA-617 AND 225AC-PSMA-617) WITH ENHANCED TUMOR CONTROL AND PROLONGED SURVIVAL IN LOW-PSMA AND TREATMENT-RESISTANT MODELS - DEMONSTRATED DURABLE ANTI-TUMOR RESPONSES, EXCEEDING THOSE ACHIEVED WITH THEARPI ENZALUTAMIDE - COMBINATION OF ATNM-400 WITHENZALUTAMIDE ACHIEVED COMPLETE TUMOR REGRESSIONIN 40% OF PROSTATE CANCER-BEARING ANIMALS, DEMONSTRATING STRONG MECHANISTIC SYNERGY WITH AR PATHWAY INHIBITION NEW YORK , OCT. 24, 2025 /PRNEWSWIRE/ -- ACTINIUM PHARMACEUTICALS, INC.(NYSE AMERICAN: ATNM) (ACTINIUM OR THE COMPANY), A PIONEER IN THE DEVELOPMENT OF DIFFERENTIATED TARGETED RADIOTHERAPIES, TODAY HIGHLIGHTED NEW PRECLINICAL DATA FOR ATNM-400, ITS NOVEL, FIRST-IN-CLASS ANTIBODY RADIOCONJUGATE ARMED WITH THE POTENT ALPHA-EMITTER ACTINIUM-225 (AC-225) AT THE 32ND ANNUAL PROSTATE CANCER FOUNDATION (PCF) SCIENTIFIC RETREAT BEING HELD OCTOBER 23  25, 2025 IN CARLSBAD, CA. ATNM-400, WHICH TARGETS A NON-PSMA ANTIGEN ASSOCIATED WITH PROSTATE CANCER PROGRESSION AND TREATMENT RESISTANCE, DEMONSTRATED SUPERIOR TUMOR CONTROL AND IMPROVED OVERALL SURVIVAL COMPARED WITH THE ACTIVE AGENTS IN KEY STANDARD-OF-CARE THERAPIES INCLUDING ENZALUTAMIDE (THE ACTIVE AGENT IN XTANDI, ASTELLAS/PFIZER) AND 177LU-PSMA-617 (THE ACTIVE AGENT IN PLUVICTO, NOVARTIS), AS WELL AS 225AC-PSMA-617 ACROSS MULTIPLE PRECLINICAL PROSTATE CANCER MODELS.

ACTINIUM PHARMACEUTICALS PRESENTS NEW DATA DEMONSTRATING POTENT AND DURABLE EFFICACY OF ATNM-400, A FIRST-IN-CLASS MULTI-TUMOR ACTINIUM-225 RADIOTHERAPY, AT THE 32ND ANNUAL PROSTATE CANCER FOUNDATION SCIENTIFIC RETREAT

ATNM-400 IS ADVANCING AS A FIRST-IN-CLASS, MULTI-TUMOR ACTINIUM-225 RADIOTHERAPY CANDIDATE WITH ACTIVITY ACROSS PROSTATE AND LUNG CANCERS, TWO OF THE LARGEST CANCER INDICATIONS GLOBALLY NEW PRECLINICAL FINDINGS DEMONSTRATE ATNM-400 OVERCOMES RESISTANCE TO THEEGFR INHIBITOR OSIMERTINIB IN EGFR-MUTATED NSCLC, ADDRESSING A MAJOR UNMET CLINICAL NEED NEW YORK , OCT. 13, 2025 /PRNEWSWIRE/ --ACTINIUM PHARMACEUTICALS, INC. (NYSE AMERICAN: ATNM), A LEADER IN THE DEVELOPMENT OF DIFFERENTIATED TARGETED RADIOTHERAPIES, TODAY ANNOUNCED THAT THE FIRST-EVER PRECLINICAL DATA FROM ITS ATNM-400 PROGRAM IN NON-SMALL CELL LUNG CANCER (NSCLC) HAS BEEN ACCEPTED FOR PRESENTATION AT THE AACR-NCI-EORTC INTERNATIONAL CONFERENCE ON MOLECULAR TARGETS AND CANCER THERAPEUTICS BEING HELD OCTOBER 22  26, 2025, AT THE HYNES CONVENTION CENTER IN BOSTON, MASSACHUSETTS. ATNM-400 IS A HIGHLY INNOVATIVE, FIRST-IN-CLASS, ACTINIUM-225 (AC-225) ANTIBODY RADIOCONJUGATE WITH PRECLINICAL DATA IN BOTH PROSTATE CANCER AND NSCLC.

ACTINIUM PHARMACEUTICALS TO UNVEIL THE MULTI-TUMOR POTENTIAL OF ATNM-400, A FIRST-IN-CLASS ACTINIUM-225 RADIOTHERAPY, WITH DATA IN NON-SMALL CELL LUNG CANCER AT THE AACR-NCI-EORTC INTERNATIONAL CONFERENCE ON MOLECULAR TARGETS AND CANCER THERAPEUTICS

- ATNM-400 TARGETS A HIGHLY DIFFERENTIATED, NON-PSMA ANTIGEN ASSOCIATED WITH THE DEVELOPMENT AND PROGRESSION OF PROSTATE CANCER, EXHIBITING POTENT THERAPEUTIC ACTIVITY INDEPENDENT OF PSMA EXPRESSION LEVELS - EXTENDED FOLLOW-UP IN PROSTATE CANCER MODELS DEMONSTRATED DURABLE ANTI-TUMOR RESPONSES WITH ATNM-400, EXCEEDING THOSE ACHIEVED WITH THE ANDROGEN RECEPTOR PATHWAY INHIBITOR (ARPI), ENZALUTAMIDE NEW YORK , OCT. 13, 2025 /PRNEWSWIRE/ -- ACTINIUM PHARMACEUTICALS, INC.(NYSE AMERICAN: ATNM) (ACTINIUM OR THE COMPANY), A PIONEER IN THE DEVELOPMENT OF DIFFERENTIATED TARGETED RADIOTHERAPIES, TODAY ANNOUNCED THAT COMPELLING PRECLINICAL DATA FOR ATNM-400, ITS NOVEL, FIRST-IN-CLASS ANTIBODY RADIOCONJUGATE ARMED WITH THE POTENT ALPHA-EMITTER ACTINIUM-225 (AC-225), HAS BEEN ACCEPTED FOR PRESENTATION AT THE 32ND ANNUAL PROSTATE CANCER FOUNDATION (PCF) SCIENTIFIC RETREAT BEING HELD ON OCTOBER 23  25, 2025 IN CARLSBAD, CA. THE PRESENTATION WILL HIGHLIGHT ATNM-400'S ABILITY TO INDUCE ROBUST, DURABLE ANTI-TUMOR ACTIVITY IN METASTATIC CASTRATION-RESISTANT PROSTATE CANCER (MCRPC) MODELS, INCLUDING TUMORS RESISTANT TO STANDARD-OF-CARE THERAPIES SUCH AS THE ANDROGEN RECEPTOR PATHWAY INHIBITOR (ARPI), ENZALUTAMIDE (XTANDI, ASTELLAS/PFIZER) AND THE PSMA-TARGETED THERAPY, 177LU-PSMA-617 (ACTIVE AGENT IN PLUVICTO, NOVARTIS) AS WELL AS SUPERIOR EFFICACY COMPARED TO 225AC-PSMA-617.

ACTINIUM TO PRESENT ATNM-400 PRECLINICAL DATA HIGHLIGHTING DURABLE TUMOR CONTROL AND ABILITY TO OVERCOME RESISTANCE TO STANDARD-OF-CARE PROSTATE CANCER THERAPIES AT THE 32ND ANNUAL PROSTATE CANCER FOUNDATION SCIENTIFIC RETREAT

-ATNM-400 DEMONSTRATES ROBUST EFFICACY IN PROSTATE CANCER TUMOR MODELS WITH ACQUIRED RESISTANCE TO PLUVICTO  AND ENZALUTAMIDE, FOLLOW-UP CONTINUES -ATNM-400 SIGNIFICANTLY IMPROVED SURVIVAL COMPARED TO THE APPROVED PROSTATE CANCER TREATMENT PLUVICTO , THE FIRST BLOCKBUSTER RADIOTHERAPY -IN COMBINATION WITH ENZALUTAMIDE, AN APPROVED ARPI THERAPY, ATNM-400 PRODUCED ENHANCED EFFICACY WITH 40% OF PROSTATE CANCER TUMOR-BEARING ANIMALS ACHIEVING COMPLETE CURES NEW YORK , JULY 31, 2025 /PRNEWSWIRE/ -- ACTINIUM PHARMACEUTICALS, INC.(NYSE AMERICAN: ATNM) (ACTINIUM OR THE COMPANY), A PIONEER IN THE DEVELOPMENT OF TARGETED RADIOTHERAPIES, TODAY REPORTED ADDITIONAL PRECLINICAL DATA SUPPORTING ITS ATNM-400 RADIOTHERAPY PROSTATE CANCER CANDIDATE AT THE 4TH ANNUAL TARGETED RADIOPHARMACEUTICALS SUMMIT (TRP) BEING HELD JULY 29  31, 2025 IN SAN DIEGO, CA. ATNM-400 IS A NOVEL, FIRST-IN-CLASS TARGETED RADIOTHERAPY DESIGNED TO DELIVER POTENT ACTINIUM-225 (AC-225), AN ALPHA-EMITTER RADIOISOTOPE, TO PROSTATE CANCER CELLS BY TARGETING A NON-PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA), DISEASE-DRIVING PROTEIN OVEREXPRESSED IN ADVANCED AND TREATMENT-RESISTANT DISEASE.

ACTINIUM PRESENTS DATA SUPPORTING PARADIGM CHANGING POTENTIAL OF ATNM-400 IN PROSTATE CANCER DEMONSTRATING ITS SUPERIOR EFFICACY AND IMPROVED SURVIVAL IN TREATMENT RESISTANT TUMOR MODELS VERSUS PLUVICTO AND ARPI THERAPY, AND ALSO ENHANCED EFFICACY IN COMBINATION WITH ARPI THERAPY AT THE 4TH ANNUAL TARGETED RADIOPHARMACEUTICALS SUMMIT

- ATNM-400 SHOWS; SUPERIOR PROSTATE CANCER CELL KILLING COMPARED TO ANDROGEN RECEPTOR INHIBITOR XTANDI (ENZALUTAMIDE), THE ABILITY TO OVERCOME XTANDI RESISTANCE, AND ACTIVITY IN COMBINATION - ATNM-400 IS MORE EFFICACIOUS THAN BOTH PLUVICTO (177-LU-PSMA-617) AND AC-225-PSMA-617 TARGETED RADIOTHERAPY IN PROSTATE CANCER IN VITRO AND IN VIVO MODELS AND OVERCOME RESISTANCE IN PROSTATE CANCER TUMORS THAT FAILED PLUVICTO THERAPY - ATNM-400'S TARGET IS HIGHLY DIFFERENTIATED FROM PSMA AS IT IS IMPLICATED IN DISEASE BIOLOGY, CONTRIBUTING TO DISEASE PROGRESSION, FASTER PROGRESSION TO CASTRATION RESISTANCE AND POORER SURVIVAL OUTCOMES WITH TARGET EXPRESSION REPORTED FOLLOWING ANDROGEN RECEPTOR INHIBITOR AND PSMA RADIOTHERAPY - DATA FURTHER SUPPORTS ATNM-400'S POTENTIAL TO ADDRESS CRITICAL GAPS IN PROSTATE CANCER TREATMENT AS A MONOTHERAPY OR IN SEQUENCE WITH OTHER THERAPEUTIC MODALITIES NEW YORK , JUNE 23, 2025 /PRNEWSWIRE/ -- ACTINIUM PHARMACEUTICALS, INC.(NYSE AMERICAN: ATNM) (ACTINIUM OR THE COMPANY), A PIONEER IN THE DEVELOPMENT OF TARGETED RADIOTHERAPIES, TODAY REPORTED NEW PRECLINICAL DATA FROM ITS FIRST-IN-CLASS, NON-PSMA TARGETING RADIOTHERAPY PROSTATE CANCER CANDIDATE ATNM-400, THAT LEVERAGES THE POTENT ALPHA-PARTICLE EMITTER ACTINIUM-225 (AC-225) ISOTOPE, AT THE SOCIETY OF NUCLEAR MEDICINE & MOLECULAR IMAGING (SNMMI) ANNUAL MEETING BEING HELD JUNE 21 ST  24TH, 2025, IN NEW ORLEANS, LOUISIANA. THE DATA PRESENTED AT SNMMI SHOWED ATNM-400 HAS SUPERIOR POTENCY COMPARED XTANDI(ENZALUTAMIDE) AND IS HIGHLY EFFICACIOUS IN XTANDIRESISTANT PROSTATE MODELS.

ACTINIUM HIGHLIGHTS EXPANDED DATA SET FOR ATNM-400 IN PROSTATE CANCER DEMONSTRATING SUPERIOR EFFICACY TO ENZALUTAMIDE AND ABILITY TO OVERCOME RESISTANCE TO ARPI THERAPY AND PSMA-AC-225/LU-177 LABELLED RADIOTHERAPY AT THE SOCIETY OF NUCLEAR MEDICINE & MOLECULAR IMAGING ANNUAL MEETING

NEW YORK , JUNE 10, 2025 /PRNEWSWIRE/ -- KUEHN LAW, PLLC, A SHAREHOLDER LITIGATION LAW FIRM, IS INVESTIGATING WHETHER CERTAIN OFFICERS AND DIRECTORS OF ACTINIUM PHARMACEUTICALS, INC. (NYSE: ATNM) BREACHED THEIR FIDUCIARY DUTIES TO SHAREHOLDERS. ACCORDING TO A FEDERAL SECURITIES LAWSUIT, INSIDERS AT ACTINIUM PHARMACEUTICALS CAUSED THE COMPANY TO MISREPRESENT OR FAIL TO DISCLOSE THAT (1) THE COMPANY'S DATA FROM THE SIERRA TRIAL WAS UNLIKELY TO SATISFY THE FDA'S GUIDELINES FOR THE ACCEPTANCE AND APPROVAL OF IOMAB-B BLA; (2) THE ADDITIONAL ANALYSES, INCLUDING LONG-TERM FOLLOW-UPS THAT PURPORTEDLY DEMONSTRATED A TREND TOWARDS IMPROVED OVERALL SURVIVAL THAT THE COMPANY PROVIDED TO THE FDA IN AN ATTEMPT TO MITIGATE SIERRA'S POOR OS DATA WERE UNLIKELY TO SATISFY THE FDA'S GUIDELINES FOR THE ACCEPTANCE AND APPROVAL OF IOMAB-B BLA; (3) AS A RESULT, THE FDA WOULD LIKELY REFUSE TO REVIEW THE IOMAB-B BLA OR, IF IT DID CONSIDER THAT BLA, THAT THE APPLICATION IN ITS CURRENT FORM WAS UNLIKELY TO BE APPROVED; AND (4), AS A RESULT, POSITIVE STATEMENTS ABOUT THE COMPANY'S BUSINESS, OPERATIONS, AND PROSPECTS WERE MATERIALLY MISLEADING AND/OR LACKED A REASONABLE BASIS.

KUEHN LAW ENCOURAGES INVESTORS OF ACTINIUM PHARMACEUTICALS, INC. TO CONTACT LAW FIRM

NEW YORK, NY / ACCESS NEWSWIRE / MAY 27, 2025 / IF YOU SUFFERED A LOSS ON YOUR ACTINIUM PHARMACEUTICALS, INC. (NYSE:ATNM) INVESTMENT AND WANT TO LEARN ABOUT A POTENTIAL RECOVERY UNDER THE FEDERAL SECURITIES LAWS, FOLLOW THE LINK BELOW FOR MORE INFORMATION: HTTPS://ZLK.COM/PSLRA-1/ACTINIUM-LAWSUIT-SUBMISSION-FORM?PRID=150393&WIRE=1&UTM_CAMPAIGN=21 OR CONTACT JOSEPH E. LEVI, ESQ.

SHAREHOLDERS OF ACTINIUM PHARMACEUTICALS, INC. (ATNM): PROTECT YOUR RIGHTS BEFORE MAY 27, 2025 - CONTACT LEVI & KORSINSKY

NEW YORK, NY / ACCESS NEWSWIRE / MAY 27, 2025 / IF YOU SUFFERED A LOSS ON YOUR ACTINIUM PHARMACEUTICALS, INC. (NYSE:ATNM) INVESTMENT AND WANT TO LEARN ABOUT A POTENTIAL RECOVERY UNDER THE FEDERAL SECURITIES LAWS, FOLLOW THE LINK BELOW FOR MORE INFORMATION: HTTPS://ZLK.COM/PSLRA-1/ACTINIUM-LAWSUIT-SUBMISSION-FORM?PRID=150356&WIRE=1&UTM_CAMPAIGN=19 OR CONTACT JOSEPH E. LEVI, ESQ.

LEVI & KORSINSKY URGES ACTINIUM (ATNM) SHAREHOLDERS TO ACT BEFORE LEAD PLAINTIFF DEADLINE MAY 27, 2025

NEW YORK, NY / ACCESS NEWSWIRE / MAY 25, 2025 / IF YOU SUFFERED A LOSS ON YOUR ACTINIUM PHARMACEUTICALS, INC. (NYSE:ATNM) INVESTMENT AND WANT TO LEARN ABOUT A POTENTIAL RECOVERY UNDER THE FEDERAL SECURITIES LAWS, FOLLOW THE LINK BELOW FOR MORE INFORMATION: HTTPS://ZLK.COM/PSLRA-1/ACTINIUM-LAWSUIT-SUBMISSION-FORM?PRID=150136&WIRE=1&UTM_CAMPAIGN=21 OR CONTACT JOSEPH E. LEVI, ESQ.

Actinium Pharmaceuticals, Inc.

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