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CRISPR Therapeutics AG, a gene editing company, focuses on developing gene-based medicines for serious diseases using its proprietary Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) platform. Its CRISPR/Cas9 is a gene editing technology that allows for precise directed changes to genomic DNA. The company has a portfolio of therapeutic programs across a range of disease areas, including hemoglobinopathies, oncology, regenerative medicine, and rare diseases. The company's lead product candidate is CTX001, an ex vivo CRISPR gene-edited therapy for treating patients suffering from transfusion-dependent beta-thalassemia or severe sickle cell disease in which a patient's hematopoietic stem cells are engineered to produce high levels of fetal hemoglobin in red blood cells. It also develops CTX110, a donor-derived gene-edited allogeneic CAR-T investigational therapy targeting cluster of differentiation 19 positive malignancies; CTX120, a donor-derived gene-edited allogeneic CAR-T investigational therapy targeting B-cell maturation antigen for the treatment of relapsed or refractory multiple myeloma; and CTX130, a donor-derived gene-edited allogeneic CAR-T investigational therapy targeting Cluster of Differentiation 70 to treat various solid tumors and hematologic malignancies. In addition, the company develops VCTX210, a gene-edited immune-evasive stem cell-derived product candidate for the treatment of treatment of type 1 diabetes; and pursues various in vivo gene-editing programs that target the liver, lung, muscle, and central nervous system diseases. It has strategic partnerships with Bayer Healthcare LLC, Vertex Pharmaceuticals Incorporated, ViaCyte, Inc., Nkarta, Inc., and Capsida Biotherapeutics. CRISPR Therapeutics AG was incorporated in 2013 and is headquartered in Zug, Switzerland.

CRISPR Therapeutics AG

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-POSITIVE PHASE 1 DATA FOR CTX310  PRESENTED IN A LATE-BREAKING PRESENTATION AT THE AMERICAN HEART ASSOCIATION (AHA) SCIENTIFIC SESSIONS AND SIMULTANEOUSLY PUBLISHED IN THE NEW ENGLAND JOURNAL OF MEDICINE- -CASGEVY  MOMENTUM ACCELERATING; NEARLY 300 PATIENTS HAVE BEEN REFERRED TO AUTHORIZED TREATMENT CENTERS (ATCS), APPROXIMATELY 165 PATIENTS HAVE COMPLETED THEIR FIRST CELL COLLECTION AND 39 HAVE RECEIVED INFUSIONS ACROSS ALL REGIONS; VERTEX EXPECTS CLEAR LINE OF SIGHT TO OVER $100 MILLION IN TOTAL CASGEVY REVENUE THIS YEAR AND SIGNIFICANT GROWTH EXPECTED IN 2026- -PEDIATRIC DEVELOPMENT OF EXA-CEL IS ADVANCING IN SCD AND TDT, WITH ENROLLMENT IN TWO GLOBAL PHASE 3 STUDIES COMPLETED; INITIAL DATA WILL BE PRESENTED AT THE UPCOMING AMERICAN SOCIETY OF HEMATOLOGY (ASH) ANNUAL MEETING- -CLINICAL TRIALS ONGOING FOR CTX112, TARGETING CD19, ACROSS MULTIPLE INDICATIONS; BROAD UPDATES FOR CTX112 IN AUTOIMMUNE DISEASE AND ONCOLOGY EXPECTED BY YEAR-END- -PRECLINICAL DATA FOR CTX460, PRESENTED AT THE EUROPEAN SOCIETY OF GENE AND CELL THERAPY (ESGCT) ANNUAL CONGRESS, DEMONSTRATED IN VIVO GENE CORRECTION OF ALPHA-1 ANTITRYPSIN DEFICIENCY (AATD) WITH A POTENTIAL BEST-IN-CLASS PROFILE; CLINICAL TRIAL INITIATION PLANNED FOR MID-2026- -PHASE 2 CLINICAL TRIAL ONGOING FOR SRSD107, TARGETING FACTOR XI FOR THE PREVENTION OF THROMBOEMBOLIC DISORDERS; FIRST PATIENT DOSED AND TRIAL EXPANDED TO ADDITIONAL SITES IN EUROPE- -STRONG BALANCE SHEET WITH APPROXIMATELY$1.9 BILLIONIN CASH, CASH EQUIVALENTS, AND MARKETABLE SECURITIES AS OFSEPTEMBER 30, 2025- ZUG, SWITZERLANDANDBOSTON, NOV. 10, 2025 (GLOBE NEWSWIRE) -- CRISPR THERAPEUTICS(NASDAQ: CRSP), A BIOPHARMACEUTICAL COMPANY FOCUSED ON CREATING TRANSFORMATIVE GENE-BASED MEDICINES FOR SERIOUS DISEASES, TODAY REPORTED FINANCIAL RESULTS FOR THE THIRD QUARTER ENDED SEPTEMBER 30, 2025. "THIS HAS BEEN ANOTHER STRONG QUARTER OF EXECUTION AND PROGRESS ACROSS OUR PORTFOLIO, SAID SAMARTH KULKARNI, PH.D.

CRISPR THERAPEUTICS PROVIDES BUSINESS UPDATE AND REPORTS THIRD QUARTER 2025 FINANCIAL RESULTS

-DATA PRESENTED IN A LATE-BREAKING PRESENTATION AT THE AMERICAN HEART ASSOCIATION (AHA) SCIENTIFIC SESSIONS 2025- -PHASE 1 CLINICAL DATA FOR CTX310 DEMONSTRATE ROBUST, DOSE-DEPENDENT REDUCTIONS IN CIRCULATING ANGPTL3 WITH A MEAN REDUCTION FROM BASELINE OF -73% (MAXIMUM -89%), A MEAN REDUCTION IN TRIGLYCERIDES (TG) OF -55% (MAXIMUM -84%), AND A MEAN REDUCTION OF LOW-DENSITY LIPOPROTEIN (LDL) OF -49% (MAXIMUM -87%) AT THE HIGHEST DOSE- -AMONG PARTICIPANTS WITH ELEVATED BASELINE TG (>150 MG/DL), A MEAN REDUCTION OF 60% IN TG WERE OBSERVED AT THERAPEUTIC DOSES- -CTX310 WAS WELL TOLERATED WITH NO TREATMENT-RELATED SERIOUS ADVERSE EVENTS AND NO GRADE 3 CHANGES IN LIVER TRANSAMINASES- -FINDINGS SIMULTANEOUSLY PUBLISHED IN THE NEW ENGLAND JOURNAL OF MEDICINE ENTITLED FIRST-IN-HUMAN PHASE 1 TRIAL OF CRISPR-CAS9 GENE EDITING TARGETING ANGPTL3- ZUG, SWITZERLAND AND BOSTON, NOV. 08, 2025 (GLOBE NEWSWIRE) -- CRISPR THERAPEUTICS(NASDAQ: CRSP), A BIOPHARMACEUTICAL COMPANY FOCUSED ON CREATING TRANSFORMATIVE GENE-BASED MEDICINES FOR SERIOUS DISEASES, TODAY ANNOUNCEDPOSITIVE PHASE 1 DATA FROM ITS ONGOING CLINICAL TRIAL EVALUATING CTX310, AN INVESTIGATIONAL, IN VIVO CRISPR/CAS9 GENE-EDITING THERAPY TARGETING ANGPTL3. A SINGLE-COURSE TREATMENT WITH CTX310 PRODUCED DOSE-DEPENDENT, DURABLE REDUCTIONS IN CIRCULATING ANGPTL3 WITH A MEAN REDUCTION FROM BASELINE OF -73% (MAXIMUM -89%), A MEAN REDUCTION IN TRIGLYCERIDES (TG) OF -55% (MAXIMUM -84%) AND A MEAN REDUCTION OF LOW-DENSITY LIPOPROTEIN (LDL) OF -49% (MAXIMUM -87%) AT THE HIGHEST DOSE.

CRISPR THERAPEUTICS ANNOUNCES POSITIVE PHASE 1 CLINICAL DATA FOR CTX310 DEMONSTRATING DEEP AND DURABLE ANGPTL3 EDITING, TRIGLYCERIDE AND LIPID LOWERING

-PRECLINICAL DATA PRESENTED AT THE EUROPEAN SOCIETY OF GENE AND CELL THERAPY (ESGCT) HIGHLIGHT A POTENTIAL BEST-IN-CLASS PROFILE-

CRISPR THERAPEUTICS PRESENTS NEW PRECLINICAL DATA FOR CTX460 DEMONSTRATING IN VIVO GENE CORRECTION OF ALPHA-1 ANTITRYPSIN DEFICIENCY (AATD) UTILIZING NOVEL SYNTASE EDITING PLATFORM

ZUG, SWITZERLAND AND BOSTON, OCT. 01, 2025 (GLOBE NEWSWIRE) -- CRISPR THERAPEUTICS (NASDAQ: CRSP), A BIOPHARMACEUTICAL COMPANY FOCUSED ON CREATING TRANSFORMATIVE GENE-BASED MEDICINES FOR SERIOUS DISEASES, TODAY ANNOUNCED THE ACCEPTANCE OF AN ABSTRACT FOR ORAL PRESENTATION AT THE EUROPEAN SOCIETY OF GENE AND CELL THERAPY (ESGCT) 2025 ANNUAL CONGRESS, TAKING PLACE OCTOBER 7-10, 2025. THE PRESENTATION WILL INTRODUCE THE COMPANY'S NOVEL SYNTASE GENE EDITING TECHNOLOGY AND HIGHLIGHT ITS APPLICATION IN SINGLE-DOSE IN VIVO GENE CORRECTION TO TREAT ALPHA-1 ANTITRYPSIN DEFICIENCY (AATD), A RARE GENETIC DISORDER.

CRISPR THERAPEUTICS TO PRESENT PRECLINICAL DATA ON ALPHA-1 ANTITRYPSIN DEFICIENCY (AATD) UTILIZING NOVEL SYNTASE GENE EDITING TECHNOLOGY AT THE EUROPEAN SOCIETY OF GENE AND CELL THERAPY (ESGCT) 2025 ANNUAL CONGRESS

ZUG, SWITZERLAND AND BOSTON, SEPT. 09, 2025 (GLOBE NEWSWIRE) -- CRISPR THERAPEUTICS (NASDAQ: CRSP), A BIOPHARMACEUTICAL COMPANY FOCUSED ON CREATING TRANSFORMATIVE GENE-BASED MEDICINES FOR SERIOUS DISEASES, TODAY ANNOUNCED THAT A LATE-BREAKING ORAL PRESENTATION HIGHLIGHTING THE COMPANY'S PHASE 1 CLINICAL DATA OF ITS INVESTIGATIONAL CRISPR/CAS9 IN VIVO GENE EDITING THERAPY, CTX310, TARGETING ANGIOPOIETIN-RELATED PROTEIN 3 (ANGPTL3) FOR CARDIOVASCULAR AND CARDIOMETABOLIC DISEASE, WILL BE PRESENTED AT THE AMERICAN HEART ASSOCIATION (AHA) SCIENTIFIC SESSIONS 2025, TAKING PLACE NOVEMBER 7  10, 2025, IN NEW ORLEANS, LOUISIANA. ADDITIONALLY, THE COMPANY WILL PRESENT A POSTER PRESENTATION ON CTX340, ITS IN VIVO PRECLINICAL PROGRAM TARGETING ANGIOTENSINOGEN (AGT) FOR THE TREATMENT OF REFRACTORY HYPERTENSION.

CRISPR THERAPEUTICS TO PRESENT LATE-BREAKING DATA AT THE AMERICAN HEART ASSOCIATION (AHA) SCIENTIFIC SESSIONS 2025

ZUG, SWITZERLANDANDBOSTON, SEPT. 02, 2025 (GLOBE NEWSWIRE) -- CRISPR THERAPEUTICS(NASDAQ: CRSP), A BIOPHARMACEUTICAL COMPANY FOCUSED ON CREATING TRANSFORMATIVE GENE-BASED MEDICINES FOR SERIOUS DISEASES, TODAY ANNOUNCED THAT MEMBERS OF ITS SENIOR MANAGEMENT TEAM ARE SCHEDULED TO PARTICIPATE IN THE FOLLOWING INVESTOR CONFERENCES IN SEPTEMBER.

CRISPR THERAPEUTICS TO PARTICIPATE IN UPCOMING INVESTOR CONFERENCES

-CASGEVY  MOMENTUM BUILDING; >75 AUTHORIZED TREATMENT CENTERS (ATCS) ACTIVATED GLOBALLY, ACHIEVING THE TARGET GOAL AND ~115 PATIENTS HAVE HAD CELLS COLLECTED ACROSS ALL REGIONS;POSITIONING THE PROGRAM FOR STRONG FUTURE GROWTH-

CRISPR THERAPEUTICS PROVIDES BUSINESS UPDATE AND REPORTS SECOND QUARTER 2025 FINANCIAL RESULTS

-NEW PHASE 1 CLINICAL DATA FOR CTX310 CONTINUES TO DEMONSTRATE DOSE-DEPENDENT REDUCTIONS IN TRIGLYCERIDES (TG) AND LOW-DENSITY LIPOPROTEIN (LDL), WITH PEAK REDUCTION OF UP TO 82% IN TG AND UP TO 86% IN LDL, WITH A WELL-TOLERATED SAFETY PROFILE-

CRISPR THERAPEUTICS REPORTS POSITIVE ADDITIONAL PHASE 1 DATA FOR CTX310 TARGETING ANGPTL3 AND PROVIDES UPDATE ON IN VIVO CARDIOVASCULAR PIPELINE

ZUG, SWITZERLAND AND BOSTON, MAY 29, 2025 (GLOBE NEWSWIRE) -- CRISPR THERAPEUTICS (NASDAQ: CRSP), A BIOPHARMACEUTICAL COMPANY FOCUSED ON CREATING TRANSFORMATIVE GENE-BASED MEDICINES FOR SERIOUS DISEASES, TODAY ANNOUNCED THAT MEMBERS OF ITS SENIOR MANAGEMENT TEAM ARE SCHEDULED TO PARTICIPATE IN THE FOLLOWING INVESTOR CONFERENCES IN JUNE. WILLIAM BLAIR'S 45 TH ANNUAL GROWTH STOCK CONFERENCE DATE: TUESDAY, JUNE 3, 2025TIME: 11:20 A.M.

-INITIAL CTX310 PHASE 1 CLINICAL DATA DEMONSTRATES DOSE-DEPENDENT DECREASES IN TRIGLYCERIDES (TG) AND LOW-DENSITY LIPOPROTEIN (LDL), WITH PEAK REDUCTION OF UP TO 82% IN TG AND UP TO 81% IN LDL, WITH A WELL-TOLERATED SAFETY PROFILE; PRESENTATION ANTICIPATED AT A MEDICAL MEETING IN THE SECOND HALF OF 2025-

CRISPR THERAPEUTICS PROVIDES FIRST QUARTER 2025 FINANCIAL RESULTS ANDANNOUNCES POSITIVE TOP-LINE DATA FROM PHASE 1 CLINICAL TRIAL OF CTX310 TARGETING ANGPTL3

CRISPR Therapeutics AG

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CRISPR Therapeutics AG

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