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Protagonist Therapeutics, Inc., a biopharmaceutical company, discovers and develops peptide-based therapeutic drugs to address hematology and blood disorders, and inflammatory and immunomodulatory diseases. It is developing rusfertide (PTG-300), an injectable hepcidin mimetic that is in Phase II clinical trials for the treatment of patients with polycythemia vera and hereditary hemochromatosis, as well as for the treatment of other blood disorders; PN-943, an oral, alpha-4-beta-7 integrin- specific antagonist peptide that is in Phase II clinical trials for treating inflammatory bowel disease (IBD); and PN-235, an orally delivered interleukin-23 receptor specific antagonist for the treatment of IBD and non-IBD indications. The company has a license and collaboration agreement with Janssen Biotech, Inc. Protagonist Therapeutics, Inc. was incorporated in 2006 and is headquartered in Newark, California.

Protagonist Therapeutics, Inc.

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NDA FOR ICOTROKINRA FOR THE TREATMENT OF ADULTS AND ADOLESCENTS 12 YEARS OF AGE AND OLDER WITH MODERATE TO SEVERE PLAQUE PSORIASIS (PSO) SUBMITTED TO U.S. FDA IN JULY ANTHEM PHASE 2B TRIAL DATA OF ICOTROKINRA IN ULCERATIVE COLITIS SCHEDULED FOR AN ORAL PRESENTATION AT THE 33RD UNITED EUROPEAN GASTROENTEROLOGY WEEK (UEGW) ON OCTOBER 7TH PHASE 3 VERIFY TRIAL DATA SET OF RUSFERTIDE IN POLYCYTHEMIA VERA (PV) PRESENTED DURING PLENARY SESSION AT ASCO; U.S. NDA FILING ON TRACK FOR Q4 CASH, CASH EQUIVALENTS AND MARKETABLE SECURITIES OF $673.0 MILLION AS OF JUNE 30, 2025, ANTICIPATED TO PROVIDE CASH RUNWAY THROUGH AT LEAST END OF 2028 NEWARK, CA / ACCESS NEWSWIRE / AUGUST 6, 2025 / PROTAGONIST THERAPEUTICS (NASDAQ:PTGX) ("PROTAGONIST" OR "THE COMPANY") TODAY REPORTED FINANCIAL RESULTS FOR THE SECOND QUARTER ENDED JUNE 30, 2025, AND PROVIDED A CORPORATE UPDATE. "THUS FAR, 2025 HAS BEEN A YEAR OF BREAKTHROUGH ACCOMPLISHMENTS FOR PROTAGONIST, AS WE SAW RUSFERTIDE THE TOPIC OF THE PRESTIGIOUS ASCO PLENARY SESSION IN MAY, THE ANNOUNCEMENT OF AN ORAL AND INJECTABLE TRIPLE AGONIST ANTI-OBESITY PEPTIDE DEVELOPMENT CANDIDATE IN JUNE, AND MOST RECENTLY THE FIRST EVER NDA FILING OF ICOTROKINRA FOR PSORIASIS LAST MONTH," SAID DINESH V.

PROTAGONIST REPORTS SECOND QUARTER 2025 FINANCIAL RESULTS AND PROVIDES CORPORATE UPDATE

WEBCAST AND CONFERENCE CALL TO BE HELD ON MONDAY, JUNE 30TH AT 4:30 PM ET, DIAL IN INFORMATION BELOW NEWARK, CA / ACCESS NEWSWIRE / JUNE 26, 2025 / PROTAGONIST THERAPEUTICS, INC. ("PROTAGONIST" OR THE "COMPANY") TODAY ANNOUNCED THAT THE COMPANY WILL HOST A CONFERENCE CALL AND WEBCAST TO ANNOUNCE ITS ORAL OBESITY DEVELOPMENT CANDIDATE AND TO SHARE IN VITRO AND PRE-CLINICAL PROOF-OF-CONCEPT STUDY RESULTS. CONFERENCE CALL AND WEBCAST DETAILS THE DIAL-IN NUMBERS FOR PROTAGONIST'S INVESTOR UPDATE ON MONDAY, JUNE 30TH AT 4:30 PM ET ARE: US-BASED INVESTORS: 1-877-407-0752INTERNATIONAL INVESTORS: 1-201-389-0912CONFERENCE CALL ID: 13754335 THE WEBCAST LINK FOR THE EVENT CAN BE FOUND HERE: HTTPS://VIAVID.WEBCASTS.COM/STARTHERE.JSP?EI=1724439&TP_KEY=584CDD1E86 A REPLAY OF THE PRESENTATION WILL BE AVAILABLE ON THE COMPANY'S INVESTOR RELATIONS EVENTS AND PRESENTATIONS WEBPAGE FOLLOWING THE EVENT.

PROTAGONIST THERAPEUTICS TO HOST CONFERENCE CALL TO ANNOUNCE AN ORAL OBESITY DEVELOPMENT CANDIDATE

NEWARK, CALIF. & OSAKA, JAPAN & CAMBRIDGE, MASS.--(BUSINESS WIRE)--PROTAGONIST THERAPEUTICS, INC. (PROTAGONIST) (NASDAQ:PTGX) AND TAKEDA (TSE:4502/NYSE:TAK) ANNOUNCED DETAILED RESULTS FROM THE PHASE 3, RANDOMIZED, PLACEBO-CONTROLLED VERIFY STUDY EVALUATING RUSFERTIDE IN PATIENTS WITH POLYCYTHEMIA VERA (PV), WHICH MET THE PRIMARY AND ALL KEY SECONDARY ENDPOINTS. THE DATA WILL BE PRESENTED AS A LATE-BREAKING ORAL PRESENTATION AT THE 61ST AMERICAN SOCIETY OF CLINICAL ONCOLOGY (ASCO) ANNUAL MEETI.

PROTAGONIST AND TAKEDA ANNOUNCE ASCO PLENARY PRESENTATION HIGHLIGHTING FULL 32-WEEK RESULTS FROM PHASE 3 VERIFY STUDY OF RUSFERTIDE, SHOWING REDUCTIONS IN PHLEBOTOMY, IMPROVED HEMATOCRIT CONTROL IN POLYCYTHEMIA VERA

NEWARK, CA / ACCESS NEWSWIRE / MAY 21, 2025 / PROTAGONIST THERAPEUTICS, INC. ("PROTAGONIST" OR THE "COMPANY") TODAY ANNOUNCED THAT DINESH V. PATEL, PH.D.

PROTAGONIST THERAPEUTICS TO PARTICIPATE IN THE JEFFERIES GLOBAL HEALTHCARE CONFERENCE 2025

POSITIVE TOP LINE RESULTS FROM RUSFERTIDE PHASE 3 VERIFY TRIAL IN POLYCYTHEMIA VERA (PV) ANNOUNCED; FULL DATA SELECTED FOR ORAL PRESENTATION DURING PLENARY SESSION AT ASCO ON JUNE 1ST CONFERENCE CALL TO BE HELD JUNE 2ND AT 8AM EDT TO DISCUSS RUSFERTIDE DATA PRESENTED AT ASCO FULL DATASET FROM PHASE 3 ICONIC-LEAD TRIAL WITH ICOTROKINRA IN PATIENTS WITH MODERATE-TO-SEVERE PLAQUE PSORIASIS (PSO) PRESENTED AT THE 2025 AAD MEETING IN MARCH; DATA FROM ADOLESCENT SUBSET PRESENTED AT WORLD CONGRESS OF PEDIATRIC DERMATOLOGY IN APRIL POSITIVE TOP LINE RESULTS FROM ICOTROKINRA PHASE 2B ANTHEM TRIAL IN MODERATELY TO SEVERELY ACTIVE ULCERATIVE COLITIS (UC) ANNOUNCED IN MARCH, DATA TO BE PRESENTED AT MEDICAL CONFERENCE LATER IN 2025 CASH, CASH EQUIVALENTS AND MARKETABLE SECURITIES OF $697.9 MILLION AS OF MARCH 31, 2025, ANTICIPATED TO PROVIDE CASH RUNWAY THROUGH AT LEAST END OF 2028 NEWARK, CALIFORNIA / ACCESS NEWSWIRE / MAY 6, 2025 / PROTAGONIST THERAPEUTICS (NASDAQ:PTGX) ("PROTAGONIST" OR "THE COMPANY") TODAY REPORTED FINANCIAL RESULTS FOR THE FIRST QUARTER ENDED MARCH 31, 2025, AND PROVIDED A CORPORATE UPDATE. "PROTAGONIST IS OFF TO A VERY STRONG 2025 WITH MULTIPLE TRANSFORMATIONAL EVENTS IN THE FIRST QUARTER FOR OUR TWO LATE-STAGE PARTNERED ASSETS, RUSFERTIDE AND ICOTROKINRA WHICH ARE PROGRESSING TO NDA FILINGS BY YEAR END," SAID DINESH V.

PROTAGONIST REPORTS FIRST QUARTER 2025 FINANCIAL RESULTS AND PROVIDES CORPORATE UPDATE

NEWARK, CA / ACCESS NEWSWIRE / APRIL 23, 2025 / PROTAGONIST THERAPEUTICS, INC. ("PROTAGONIST" OR THE "COMPANY") ANNOUNCED THAT AN ABSTRACT WAS ACCEPTED FOR PRESENTATION AT THE PLENARY SESSION AT THE AMERICAN SOCIETY OF CLINICAL ONCOLOGY (ASCO) ANNUAL MEETING BEING HELD MAY 30 - JUNE 3, 2025. PRESENTATION DETAILS: PRESENTING AUTHOR: ANDREW T.

PROTAGONIST THERAPEUTICS ANNOUNCES PLENARY PRESENTATION ON VERIFY PHASE 3 STUDY WITH RUSFERTIDE AT ASCO 2025

NEWARK, CA / ACCESS NEWSWIRE / APRIL 16, 2025 / PROTAGONIST THERAPEUTICS, INC. ("PROTAGONIST" OR THE "COMPANY"), A CLINICAL-STAGE BIOPHARMACEUTICAL COMPANY PIONEERING THE DISCOVERY AND DEVELOPMENT OF PEPTIDE-BASED THERAPEUTICS, TODAY ANNOUNCED THAT ON APRIL 15, 2025 (THE "GRANT DATE"), IT ISSUED AN EQUITY INDUCEMENT AWARD TO A NEW EMPLOYEE UPON HIS COMMENCEMENT OF EMPLOYMENT WITH THE COMPANY IN ACCORDANCE WITH THE TERMS OF HIS EMPLOYMENT OFFER LETTER. THE AWARD WAS GRANTED UNDER THE COMPANY'S AMENDED AND RESTATED 2018 INDUCEMENT PLAN, WHICH WAS ADOPTED ON MAY 29, 2018, AND AMENDED ON FEBRUARY 18, 2020 AND FEBRUARY 15, 2022.

PROTAGONIST THERAPEUTICS REPORTS GRANTING OF INDUCEMENT AWARD

PAST WINNERS INCLUDE WAYMO, NVIDIA, DUOLINGO, AND NOVO NORDISK, AMONG OTHERS NEWARK, CA / ACCESS NEWSWIRE / MARCH 18, 2025 / PROTAGONIST THERAPEUTICS, INC. ("PROTAGONIST" OR THE "COMPANY"), A CLINICAL-STAGE BIOPHARMACEUTICAL COMPANY PIONEERING THE DISCOVERY AND DEVELOPMENT OF PEPTIDE-BASED THERAPEUTICS, TODAY ANNOUNCED ITS INCLUSION IN FAST COMPANY'S PRESTIGIOUS ANNUAL LIST OF THE WORLD'S MOST INNOVATIVE COMPANIES FOR 2025. FAST COMPANY'S ANNUAL LIST OF THE WORLD'S MOST INNOVATIVE COMPANIES SPOTLIGHTS ORGANIZATIONS ACROSS VARIOUS INDUSTRIES THAT ARE DRIVING MEANINGFUL CHANGE THROUGH GROUNDBREAKING IDEAS AND TRANSFORMATIVE TECHNOLOGIES.

PROTAGONIST THERAPEUTICS NAMED TO FAST COMPANY'S ANNUAL LIST OF THE WORLD'S MOST INNOVATIVE COMPANIES OF 2025

NEWARK, CALIF. & OSAKA, JAPAN & CAMBRIDGE, MASS.--(BUSINESS WIRE)--PROTAGONIST THERAPEUTICS, INC. (PROTAGONIST) (NASDAQ:PTGX) AND TAKEDA (TSE:4502/NYSE:TAK) TODAY ANNOUNCED POSITIVE TOPLINE RESULTS FOR THE PHASE 3 VERIFY STUDY, IN WHICH PHLEBOTOMY-DEPENDENT PATIENTS WITH POLYCYTHEMIA VERA (PV) WERE RANDOMIZED TO TREATMENT WITH EITHER RUSFERTIDE OR PLACEBO, AS AN ADD-ON TO STANDARD OF CARE TREATMENT. THE STUDY MET ITS PRIMARY ENDPOINT AND ALL FOUR KEY SECONDARY ENDPOINTS. RUSFERTIDE IS A FIRST.

PROTAGONIST AND TAKEDA ANNOUNCE POSITIVE TOPLINE RESULTS FROM PHASE 3 VERIFY STUDY OF RUSFERTIDE IN PATIENTS WITH POLYCYTHEMIA VERA

$165.0 MILLION ICOTROKINRA (FORMERLY JNJ-2113) MILESTONE EARNED IN Q4 2024, RECEIVED IN JANUARY 2025 PN-881, A POTENTIAL BEST-IN-CLASS ORAL IL-17 RECEPTOR ANTAGONIST PEPTIDE NOMINATED AS A DEVELOPMENT CANDIDATE IN Q4 2024 TOPLINE RESULTS FOR RUSFERTIDE PHASE 3 VERIFY CLINICAL TRIAL IN POLYCYTHEMIA VERA EXPECTED IN MARCH 2025 TOPLINE RESULTS FOR ICOTROKINRA PHASE 2B ANTHEM CLINICAL TRIAL IN MODERATE TO SEVERE ULCERATIVE COLITIS EXPECTED IN MARCH 2025 CASH, CASH EQUIVALENTS, AND MARKETABLE SECURITIES OF $559.2 MILLION AS OF DECEMBER 31, 2024, COMBINED WITH $165.0 MILLION MILESTONE PAYMENT, ANTICIPATED TO PROVIDE CASH RUNWAY THROUGH AT LEAST END OF 2028 NEWARK, CA / ACCESS NEWSWIRE / FEBRUARY 21, 2025 / PROTAGONIST THERAPEUTICS (NASDAQ:PTGX) ("PROTAGONIST" OR "THE COMPANY") TODAY REPORTED FINANCIAL RESULTS FOR THE FOURTH QUARTER AND FULL YEAR ENDED DECEMBER 31, 2024, AND PROVIDED A CORPORATE UPDATE. "PROTAGONIST IS QUICKLY APPROACHING MULTIPLE LATE-STAGE TRANSFORMATIONAL EVENTS EXPECTED IN THE FIRST QUARTER OF THIS YEAR, INCLUDING THE TOPLINE RESULTS FROM THE VERIFY PHASE 3 STUDY OF RUSFERTIDE IN POLYCYTHEMIA VERA AND FROM THE ANTHEM PHASE 2B ULCERATIVE COLITIS STUDY OF ICOTROKINRA," SAID DINESH V.

Protagonist Therapeutics, Inc.

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