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Pyxis Oncology, Inc., a preclinical stage biopharmaceutical company, engages in the development of therapies to treat cancers. Its immune-oncology product candidates include PYX-106, an investigational fully human immunoglobulin G1 isotype siglec-15 targeting antibody for the treatment of thyroid cancer, head and neck squamous cell carcinoma, non-small cell lung cancer (NSCLC), and other solid tumors; and PYX-102, an investigational immune-therapeutic for treatment of solid tumors. The company's antibody drug conjugate (ADC) product candidates comprise of PYX-201, an investigational novel ADC to treat NSCLC, breast cancer, and other solid tumors; PYX-202, an investigational novel ADC for treatment of SCLC, soft tissue sarcoma, and other solid tumors; and PYX-203, an investigational ADC for the treatment of acute myeloid leukemia and myeloid dysplastic syndrome. The company was incorporated in 2018 and is headquartered in Cambridge, Massachusetts.

Pyxis Oncology, Inc.

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EXPECTED TO EXTEND CASH RUNWAY INTO THE SECOND QUARTER OF 2027, SUPPORTING ADDITIONAL FOLLOW-UP FOR 2L+ R/M HNSCC PATIENTS TREATED WITH MICVO AT OR BELOW A DOSE CAP

PYXIS ONCOLOGY ANNOUNCES UP TO $114 MILLION PRIVATE PLACEMENT FINANCING TO ADVANCE MICVO THROUGH KEY CLINICAL MILESTONES

UPDATED MICVOTABART PELIDOTIN (MICVO) PHASE 1 MONOTHERAPY DATA IN 2L+ RECURRENT/METASTATIC HEAD AND NECK SQUAMOUS CELL CARCINOMA (R/M HNSCC) ON TRACK FOR MID-YEAR 2026; UPDATE TO INCLUDE ANALYSES FOCUSED ON PATIENTS TREATED AT OR BELOW A DOSE CAP COMPLETED TARGET ENROLLMENT IN PHASE 1 MONOTHERAPY DOSE EXPANSION STUDY OF MICVO IN 2L+ R/M HNSCC IN THE FIRST QUARTER OF 2026 UPDATED DATA FROM MICVO PHASE 1/2 DOSE ESCALATION STUDY IN COMBINATION WITH PEMBROLIZUMAB IN 1L R/M HNSCC ON TRACK FOR THE SECOND HALF OF 2026 PRESENTED NEW PRECLINICAL DATA AT THE AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR) ANNUAL MEETING 2026 THAT SUPPORT THE CLINICAL DEVELOPMENT OF MICVO AS BOTH A MONOTHERAPY AND IN COMBINATION WITH PEMBROLIZUMAB FOR THE TREATMENT OF R/M HNSCC ANNOUNCED THE APPOINTMENT OF NELSON AZOULAY AS CHIEF BUSINESS OFFICER    EXPECTED CASH RUNWAY INTO THE FOURTH QUARTER OF 2026 BOSTON, MAY 14, 2026 (GLOBE NEWSWIRE) -- PYXIS ONCOLOGY, INC. (NASDAQ: PYXS), A CLINICAL-STAGE COMPANY DEVELOPING NEXT-GENERATION THERAPEUTICS FOR DIFFICULT-TO-TREAT CANCERS, TODAY REPORTED FINANCIAL RESULTS FOR THE QUARTER ENDED MARCH 31, 2026, AND HIGHLIGHTED CONTINUED ADVANCEMENT OF THE MICVOTABART PELIDOTIN (MICVO) CLINICAL DEVELOPMENT PROGRAM. OUR TEAM'S EXCEPTIONAL CLINICAL AND OPERATIONAL EXECUTION IN THE FIRST QUARTER OF 2026, COMBINED WITH GROWING INVESTIGATOR ENTHUSIASM FOR MICVO'S POTENTIAL TO POSITIVELY IMPACT THE LIVES OF PATIENTS WITH CANCER, HAS POSITIONED US TO DELIVER KEY MILESTONES FOR THE MICVO PROGRAM THIS YEAR, SAID TOM CIVIK, INTERIM CHIEF EXECUTIVE OFFICER AND DIRECTOR OF PYXIS ONCOLOGY.

PYXIS ONCOLOGY REPORTS FIRST QUARTER 2026 FINANCIAL RESULTS AND ADVANCES MICVO TOWARD KEY 2026 CLINICAL MILESTONES

BOSTON, MAY 13, 2026 (GLOBE NEWSWIRE) -- PYXIS ONCOLOGY, INC. (NASDAQ: PYXS), A CLINICAL-STAGE COMPANY DEVELOPING NEXT-GENERATION THERAPEUTICS FOR DIFFICULT-TO-TREAT CANCERS, TODAY ANNOUNCED THAT MANAGEMENT WILL PARTICIPATE IN THE FOLLOWING UPCOMING INVESTOR CONFERENCES:

PYXIS ONCOLOGY TO PARTICIPATE IN UPCOMING INVESTOR CONFERENCES

BOSTON, MAY 07, 2026 (GLOBE NEWSWIRE) -- PYXIS ONCOLOGY, INC. (NASDAQ: PYXS), A CLINICAL-STAGE COMPANY DEVELOPING NEXT-GENERATION THERAPEUTICS FOR DIFFICULT-TO-TREAT CANCERS, TODAY ANNOUNCED THE APPOINTMENT OF NELSON AZOULAY AS CHIEF BUSINESS OFFICER.

PYXIS ONCOLOGY APPOINTS NELSON AZOULAY AS CHIEF BUSINESS OFFICER

MOUSE ANALOG OF MICVO (MAMICVO) MONOTHERAPY PRODUCED DOSE-DEPENDENT INHIBITION OF TUMOR GROWTH IN A SYNGENEIC PRECLINICAL MODEL OF HNSCC

PYXIS ONCOLOGY TO PRESENT NEW PRECLINICAL DATA SHOWING SYNERGISTIC ANTI-TUMOR ACTIVITY IN A HNSCC MODEL WITH MAMICVO IN COMBINATION WITH ANTI-PD-1 AT AACR 2026

COMPLETED TARGET ENROLLMENT IN PHASE 1 MONOTHERAPY DOSE EXPANSION STUDY OF MICVOTABART PELIDOTIN (MICVO) IN 2L+ RECURRENT/METASTATIC HEAD AND NECK SQUAMOUS CELL CARCINOMA (R/M HNSCC) IN THE FIRST QUARTER OF 2026

PYXIS ONCOLOGY PROVIDES BUSINESS UPDATE AND REPORTS FOURTH QUARTER AND FULL YEAR 2025 FINANCIAL RESULTS

BOSTON, FEB. 03, 2026 (GLOBE NEWSWIRE) -- PYXIS ONCOLOGY, INC. (NASDAQ: PYXS), A CLINICAL-STAGE COMPANY DEVELOPING NEXT-GENERATION THERAPEUTICS FOR DIFFICULT-TO-TREAT CANCERS, TODAY ANNOUNCED A LEADERSHIP TRANSITION TO CONTINUE EXECUTION AND ADVANCEMENT OF THE COMPANY'S STRATEGIC AND CLINICAL GOALS.

PYXIS ONCOLOGY ANNOUNCES INTERIM CEO APPOINTMENT AND LEADERSHIP TRANSITION TO SUPPORT STRATEGIC FOCUS AND PROGRAM CONTINUITY

BOSTON, DEC. 18, 2025 (GLOBE NEWSWIRE) -- PYXIS ONCOLOGY, INC. (NASDAQ: PYXS), A CLINICAL-STAGE COMPANY DEVELOPING NEXT-GENERATION THERAPEUTICS FOR DIFFICULT-TO-TREAT CANCERS, TODAY ANNOUNCED POSITIVE PRELIMINARY DATA FROM ITS ONGOING PHASE 1 CLINICAL STUDIES EVALUATING MICVOTABART PELIDOTIN (MICVO), A FIRST-IN-CONCEPT ANTIBODY-DRUG CONJUGATE (ADC) TARGETING EXTRADOMAIN-B OF FIBRONECTIN (EDB+FN), A NON-CELLULAR STRUCTURAL COMPONENT OF THE TUMOR EXTRACELLULAR MATRIX (ECM), IN PATIENTS WITH RECURRENT/METASTATIC HEAD AND NECK SQUAMOUS CELL CARCINOMA (R/M HNSCC). THE UPDATE INCLUDES PRELIMINARY DATA FROM BOTH THE PHASE 1 MONOTHERAPY STUDY IN 2L+ R/M HNSCC AND THE PHASE 1/2 STUDY EVALUATING MICVO IN COMBINATION WITH MERCK'S (KNOWN AS MSD OUTSIDE OF THE US AND CANADA) ANTI-PD-1 THERAPY, PEMBROLIZUMAB, IN 1L/2L+ R/M HNSCC.

PYXIS ONCOLOGY ANNOUNCES POSITIVE PRELIMINARY PHASE 1 DATA FOR MICVOTABART PELIDOTIN (MICVO) IN RECURRENT/METASTATIC HEAD AND NECK SQUAMOUS CELL CARCINOMA

BOSTON, NOV. 03, 2025 (GLOBE NEWSWIRE) -- PYXIS ONCOLOGY, INC. (NASDAQ: PYXS), A CLINICAL-STAGE COMPANY DEVELOPING NEXT-GENERATION THERAPEUTICS FOR DIFFICULT-TO-TREAT CANCERS, TODAY ANNOUNCED THAT MANAGEMENT WILL PARTICIPATE IN THE FOLLOWING UPCOMING INVESTOR CONFERENCES IN NOVEMBER 2025:

- PRELIMINARY DATA FROM ONGOING PHASE 1 CLINICAL STUDIES OF MICVOTABART PELIDOTIN (MICVO) IN PATIENTS WITH RECURRENT AND METASTATIC HEAD AND NECK SQUAMOUS CELL CARCINOMA (R/M HNSCC) EXPECTED IN THE FOURTH QUARTER OF 2025 - CLINICAL UPDATE TO FOCUS ON PRELIMINARY DATA FROM PHASE 1 MONOTHERAPY DOSE EXPANSION STUDY OF MICVO IN 2L/3L R/M HNSCC PATIENTS, INCLUDING FROM BOTH POST PLATINUM & PD-1 AND POST EGFR & PD-1 ARMS, AND PRELIMINARY DATA FROM PHASE 1/2 COMBINATION DOSE ESCALATION STUDY OF MICVO AND KEYTRUDA (PEMBROLIZUMAB) IN 1L/2L+ R/M HNSCC PATIENTS - PRESENTED TRANSLATIONAL DATA AT ESMO 2025 AND AACR-NCI-EORTC PROVIDING MEANINGFUL INSIGHTS INTO MICVO'S FIRST-IN-CONCEPT NON-CELLULAR TARGETING ANTIBODY DRUG CONJUGATE (ADC) MECHANISM OF ACTION - EXPECTED CASH RUNWAY THROUGH DATA MILESTONES AND INTO THE SECOND HALF OF 2026 BOSTON, NOV. 03, 2025 (GLOBE NEWSWIRE) -- PYXIS ONCOLOGY, INC. (NASDAQ: PYXS), A CLINICAL-STAGE COMPANY DEVELOPING NEXT-GENERATION THERAPEUTICS FOR DIFFICULT-TO-TREAT CANCERS, TODAY PROVIDED A BUSINESS UPDATE, AND REPORTED FINANCIAL RESULTS FOR THE QUARTER ENDED SEPTEMBER 30, 2025. IN THE DYNAMIC LANDSCAPE OF EMERGING CLINICAL-STAGE THERAPIES FOR PATIENTS WITH RECURRENT AND METASTATIC HEAD AND NECK SQUAMOUS CELL CARCINOMA, A SIGNIFICANT UNMET MEDICAL NEED REMAINS DESPITE THE POTENTIAL IMPROVEMENTS IN TREATMENT OPTIONS, SAID LARA S.

Pyxis Oncology, Inc.

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