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Solid Biosciences Inc. engages in developing therapies for duchenne muscular dystrophy in the United States. The company's lead product candidate is SGT-001, a gene transfer candidate, which is in a Phase I/II clinical trial to drive functional dystrophin protein expression in patients' muscles; and SGT-003, a ext-generation gene transfer candidate for the treatment of duchenne muscular dystrophy. It also engages in developing of platform technologies, including dual gene expression, a technology for packaging multiple transgenes into one vector, as well as novel capsids. The company has collaboration and license agreement with Ultragenyx Pharmaceutical Inc. to develop and commercialize new gene therapies for Duchenne Muscular Dystrophy. Solid Biosciences Inc. was incorporated in 2013 and is headquartered in Cambridge, Massachusetts.

Solid Biosciences Inc.

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CHARLESTOWN, MASS., DEC. 16, 2025 (GLOBE NEWSWIRE) -- SOLID BIOSCIENCES INC. (NASDAQ: SLDB) (THE COMPANY OR SOLID), A LIFE SCIENCES COMPANY DEVELOPING PRECISION GENETIC MEDICINES FOR NEUROMUSCULAR AND CARDIAC DISEASES, TODAY SHARED THAT THE U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES (HHS) OFFICIALLY ADDED DUCHENNE MUSCULAR DYSTROPHY (DUCHENNE) TO THE RECOMMENDED UNIFORM SCREENING PANEL (RUSP), THE LIST OF CONDITIONS RECOMMENDED FOR UNIVERSAL NEWBORN SCREENING ACROSS THE UNITED STATES.

SOLID BIOSCIENCES ANNOUNCES DUCHENNE MUSCULAR DYSTROPHY ADDED TO NATIONAL RECOMMENDED UNIFORM SCREENING PANEL BY THE U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES

CHARLESTOWN, MASS., DEC. 08, 2025 (GLOBE NEWSWIRE) -- SOLID BIOSCIENCES INC. (NASDAQ: SLDB) (THE COMPANY OR SOLID), A LIFE SCIENCES COMPANY DEVELOPING PRECISION GENETIC MEDICINES FOR NEUROMUSCULAR AND CARDIAC DISEASES, TODAY ANNOUNCED THAT IT WILL PRESENT DATA FROM ITS NEXT-GENERATION, PROPRIETARY CAPSID AAV-SLB101 AND ITS CARDIAC GENE THERAPY PIPELINE AT THE GLOBAL CARDIOVASCULAR CLINICAL TRIALISTS (CVCT) FORUM TAKING PLACE DECEMBER 8-10, 2025, IN WASHINGTON, D.C.

SOLID BIOSCIENCES TO SHOWCASE PROPRIETARY NEXT-GENERATION CAPSID AAV-SLB101 AND CARDIAC GENE THERAPY PIPELINE AT THE 22ND GLOBAL CARDIOVASCULAR CLINICAL TRIALISTS (CVCT) FORUM

CHARLESTOWN, MASS., DEC. 01, 2025 (GLOBE NEWSWIRE) -- SOLID BIOSCIENCES INC. (NASDAQ: SLDB) (THE COMPANY), A LIFE SCIENCES COMPANY DEVELOPING PRECISION GENETIC MEDICINES FOR NEUROMUSCULAR AND CARDIAC DISEASES, TODAY ANNOUNCED GRANTS OF 23,284 RESTRICTED STOCK UNITS (RSUS) TO TWO NEWLY HIRED EMPLOYEES.

SOLID BIOSCIENCES REPORTS INDUCEMENT GRANTS UNDER NASDAQ LISTING RULE 5635(C)(4)

 SGT-212 HAS BEEN GRANTED FDA RARE PEDIATRIC DISEASE AND FAST TRACK DESIGNATIONS  SGT-212 IS THE ONLY DUAL ROUTE GENE THERAPY IN DEVELOPMENT TO TREAT FRIEDREICH'S ATAXIA   FALCON PHASE 1B CLINICAL TRIAL PARTICIPANT SCREENING UNDERWAY  CHARLESTOWN, MASS., DEC. 01, 2025 (GLOBE NEWSWIRE) -- SOLID BIOSCIENCES INC. (NASDAQ: SLDB) (THE COMPANY OR SOLID), A LIFE SCIENCES COMPANY DEVELOPING PRECISION GENETIC MEDICINES FOR NEUROMUSCULAR AND CARDIAC DISEASES, TODAY ANNOUNCED THAT IT RECEIVED RARE PEDIATRIC DISEASE DESIGNATION FROM THE U.S. FOOD AND DRUG ADMINISTRATION (FDA) FOR SGT-212, THE COMPANY'S INVESTIGATIONAL GENE THERAPY FOR FRIEDREICH'S ATAXIA (FA).

SOLID BIOSCIENCES RECEIVES FDA RARE PEDIATRIC DISEASE DESIGNATION FOR SGT-212 DUAL ROUTE OF ADMINISTRATION GENE THERAPY FOR FRIEDREICH'S ATAXIA

- NON-EXCLUSIVE LICENSE PROVIDING SOLID'S PROPRIETARY, NEXT-GENERATION CAPSID, AAV-SLB101, TO ANDELYN BIOSCIENCES, A FULL-SERVICE CELL AND GENE THERAPY CONTRACT DEVELOPMENT AND MANUFACTURING ORGANIZATION (CDMO) - - AAV-SLB101 HAS BEEN GENERALLY WELL TOLERATED IN THE 23 PARTICIPANTS DOSED IN THE PHASE 1/2 INSPIRE DUCHENNE CLINICAL TRIAL AS OF A SAFETY CUTOFF OF OCTOBER 31, 2025 -

SOLID BIOSCIENCES ANNOUNCES LICENSING AGREEMENT WITH ANDELYN BIOSCIENCES FOR THE USE OF PROPRIETARY NEXT-GENERATION CAPSID AAV-SLB101

CHARLESTOWN, MASS., NOV. 11, 2025 (GLOBE NEWSWIRE) -- SOLID BIOSCIENCES INC. (NASDAQ: SLDB) (THE COMPANY OR SOLID), A LIFE SCIENCES COMPANY DEVELOPING PRECISION GENETIC MEDICINES FOR NEUROMUSCULAR AND CARDIAC DISEASES, TODAY ANNOUNCED PARTICIPATION IN THE FOLLOWING INVESTOR CONFERENCES:

SOLID BIOSCIENCES TO PARTICIPATE AT UPCOMING INVESTOR CONFERENCES

CHARLESTOWN, MASS., NOV. 04, 2025 (GLOBE NEWSWIRE) -- SOLID BIOSCIENCES INC. (NASDAQ: SLDB) (THE COMPANY), A LIFE SCIENCES COMPANY DEVELOPING PRECISION GENETIC MEDICINES FOR NEUROMUSCULAR AND CARDIAC DISEASES, TODAY ANNOUNCED GRANTS OF 26,550 RESTRICTED STOCK UNITS (RSUS) TO TWO NEWLY HIRED EMPLOYEES.

- DUCHENNE (SGT-003): 23 PARTICIPANTS HAVE BEEN DOSED IN THE INSPIRE DUCHENNE TRIAL AS OF OCTOBER 31, 2025; SOLID EXPECTS TO HAVE DOSED 30 PARTICIPANTS IN TOTAL BY EARLY 2026, THEN PLANS TO MEET WITH THE FDA TO DISCUSS POTENTIAL REGISTRATIONAL PATHWAYS IN H1 2026 - - SGT-003 HAS BEEN GENERALLY WELL TOLERATED USING A STEROID-ONLY PROPHYLACTIC IMMUNOMODULATION REGIMEN; CARDIAC SAFETY MONITORING CONTINUED TO SHOW REDUCTION IN CARDIAC INJURY AND EARLY SIGNALS OF CARDIAC FUNCTION NORMALIZATION - - DAY 90 BIOPSY DATA FROM 10 TREATED PARTICIPANTS (AGES 5-10) SHOWED ALL PARTICIPANTS RESPONDED TO TREATMENT WITH MEAN MICRODYSTROPHIN EXPRESSION OF 58% BY WESTERN BLOT, 58% BY MASS SPECTROMETRY, MEAN MICRODYSTROPHIN POSITIVE FIBERS OF 51% BY IMMUNOFLUORESCENCE, AND MEAN BETA- SARCOGLYCAN POSITIVE FIBERS OF 50% BY IMMUNOFLUORESCENCE - - STRONG STATISTICAL CORRELATIONS OBSERVED BETWEEN DAY 90 MICRODYSTROPHIN EXPRESSION LEVELS AND KEY COMPONENTS OF THE DYSTROPHIN-ASSOCIATED PROTEIN COMPLEX (DAPC), BETA-SARCOGLYCAN (R = 0.95) AND NNOS (R = 0.95), DEMONSTRATED EVIDENCE OF SGT-003-MEDIATED DAPC RESTORATION AND CONCORDANT SIGNALS OF MUSCLE PROTECTION VIA REDUCTIONS IN CK LEVELS (R = -0.78) - - SOLID HAS ACTIVATED THE FIRST CLINICAL TRIAL SITE AND IS CURRENTLY SCREENING PARTICIPANTS FOR IMPACT DUCHENNE, A PHASE 3 RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED EX-U.S. CLINICAL TRIAL OF SGT-003 - - FA (SGT-212): SOLID HAS ACTIVATED THE FIRST CLINICAL TRIAL SITE AND IS CURRENTLY SCREENING PARTICIPANTS FOR FALCON, A PHASE 1B FIRST-IN-HUMAN CLINICAL TRIAL EVALUATING SGT-212 FOR THE TREATMENT OF FRIEDREICH'S ATAXIA - - CPVT (SGT-501): CLINICAL TRIAL SITE ACTIVATION FOR ARTEMIS, A PHASE 1B FIRST-IN-HUMAN CLINICAL TRIAL EVALUATING SGT-501 FOR THE TREATMENT OF CATECHOLAMINERGIC POLYMORPHIC VENTRICULAR TACHYCARDIA EXPECTED IN Q4 2025 - - CAPSIDS (AAV-SLB101): OVER 30 AGREEMENTS INCLUDING LICENSES EXECUTED WITH CORPORATIONS, INSTITUTIONS, AND ACADEMIC LABS FOR THE USE OF AAV-SLB101 - - CASH: COMPANY

SOLID BIOSCIENCES REPORTS THIRD QUARTER 2025 FINANCIAL RESULTS AND PROVIDES UPDATE ON INSPIRE DUCHENNE CLINICAL TRIAL PROGRESS AND PLANNED REGULATORY DISCUSSIONS

CHARLESTOWN, MASS., OCT. 30, 2025 (GLOBE NEWSWIRE) -- SOLID BIOSCIENCES INC. (NASDAQ: SLDB) (THE COMPANY OR SOLID), A LIFE SCIENCES COMPANY DEVELOPING PRECISION GENETIC MEDICINES FOR NEUROMUSCULAR AND CARDIAC DISEASES, TODAY ANNOUNCED PARTICIPATION IN THE FOLLOWING INVESTOR CONFERENCES: 2025 TRUIST SECURITIES BIOPHARMA SYMPOSIUM DR. GABRIEL BROOKS, CHIEF MEDICAL OFFICER, WILL PARTICIPATE IN A PANEL DISCUSSION TITLED PRECISION MEDICINE: DMD, FA, AND BEYOND ON THURSDAY, NOVEMBER 6, 2025, AT 1:40 P.M.

CHARLESTOWN, MASS., OCT. 01, 2025 (GLOBE NEWSWIRE) -- SOLID BIOSCIENCES INC. (NASDAQ: SLDB) (THE COMPANY), A LIFE SCIENCES COMPANY DEVELOPING PRECISION GENETIC MEDICINES FOR NEUROMUSCULAR AND CARDIAC DISEASES, TODAY ANNOUNCED GRANTS OF 116,150 RESTRICTED STOCK UNITS (RSUS) TO FOUR NEWLY HIRED EMPLOYEES.

CHARLESTOWN, MASS., OCT. 01, 2025 (GLOBE NEWSWIRE) -- SOLID BIOSCIENCES INC. (NASDAQ: SLDB), A LIFE SCIENCES COMPANY DEVELOPING PRECISION GENETIC MEDICINES FOR NEUROMUSCULAR AND CARDIAC DISEASES, WILL PRESENT DATA FROM ITS NEUROMUSCULAR AND CARDIAC PROGRAMS AT THE WORLD MUSCLE SOCIETY (WMS) 2025 ANNUAL INTERNATIONAL CONGRESS, OCTOBER 7-11, 2025, IN VIENNA, AUSTRIA, AND AT THE EUROPEAN SOCIETY OF GENE & CELL THERAPY (ESGCT) 2025 ANNUAL CONGRESS, OCTOBER 7-12, 2025, IN SEVILLE, SPAIN.

Solid Biosciences Inc.

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